Endocrine Abstracts

GLP-1 is a gut hormones with insulinotropic effects. GLP-1 is expressed at the hypothalamus having regulatory functions in food intake and neuroendocrine corticoadrenal axis (HPA). Energy balance and HPA have deep influence in the gonadal function of mammals. Exendin-4 (Ex4) is a potent agonist for the GLP-1 receptor.Objectives: To evaluate the effects of native GLP-1 (7–36)-NH2(GLP-1) and Ex4 in the function of the reproductive system in adulthood ...

Introduction: Diabetes mellitus is a condition on the increase, carrying a high risk of cardiovascular complications. It is, also, well known that diabetes confers a substantial burden of microvascular disease. Previous studies suggest a link between microvascular and macrovascular events in diabetes. However, just a few studies have investigated whether the presence of previous cardiovascular events is associated with microvascular disease in diabetes patients. So, this is th...

Acromegaloidisms are usually reported as isolated cases that are not well characterised clinically. Indeed, most such cases were reported several decades ago, part of the reason why our knowledge about this entity is scarce. By contrast, clinical situations suggestive of acromegaly are not so infrequent, in which basal GH and IGF1 levels lie within a normal range, the GH responses to OGTT challenge are conserved and there is no radiological (MRI) evidence of hypothalamic-pitui...

Introduction: CDKN1B gene, which encodes a cyclin-dependent kinase (Cdk) inhibitor, regulates the progression throughout G1 to S cell cycle progression. CDKN1B loss-of-function germinal mutations cause the multiple endocrine neoplasia type 4 syndrome (MEN4).Objective: The aim of the study is the functional characterization of a new 4 bp deletion in CDKN1B 5′-UTR region, identified in an acromegalic patient.Materials and metho...

Increased serum TSH has been reported in obese children and adolescents and is considered an adaptive mechanism secondary to obesity. This study was undertaken to test the hypothesis that this adaptation is not associated with obesity per se but with its related metabolic alterations. Using a cross-sectional approach, we collected retrospectively fasting serum TSH concentration (if within the normal range), anthropometric parameters and criteria for the diagnosis of t...

Objectives: Prognosis of differentiated thyroid carcinoma (DTC) is usually good, but even so a proportion of the patients develop recurrences and eventually die of the disease. The aim of this study was to analyze the clinical and histopathological features of patients with DTC in our center and to identify prognostic factors in this group of patients.Patients and methods: We reviewed, retrospectively, 213 patients (184 females and 29 males, mean age 48....

The 46 XX male syndrome (de la Chapelle syndrome or 46,XX testicular disorder of sex development -46,XX testicular DSD-) is a rare phenotype associated with disorder of the sex chromosomes. XX males exist in different clinical categories with ambiguous genitalia or partially to fully mature male genitalia, in combination with complete or incomplete masculinization.Clinical report: We describe the clinical, molecular, and cytogenetic findings of a 26-year...

Objective: One of the major problems related to the use of CSII, or intensive insulin regimens in general, is the calculation of accurate insulin boluses. Abolus calculator incorporated into the insulin pump, estimates the dose of insulin to be administered at the meal on the basis of the following parameters: current blood glucose, grams of carbohydrate in the meal, carbohydrate to-insulin ratio (CIR), insulin sensitivity factors (ISF), target blood glucose and quantity of in...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

Objective: We retrospectively analyzed patients with type 1 diabetes onset, attended during the years 2005 and 2006 on the specific query of type 1 DM debut of a tertiary hospital, with initial treatment assessment, at 1 and 5 years evolution.Results: Patients were treated for newly diagnosed DM 1, 25 patients (72% male, 28% female) mean age 23.2 years (14–36), mean BMI: 23.18 (18–33.8%).The clinical presentation included: 88.24% presented with...